Table 1 A comparison of gates between human PANX1 and zebrafish Panx1a/Panx1b.

From: Panx1 channels promote both anti- and pro-seizure-like activities in the zebrafish via p2rx7 receptors and ATP signaling

 

Human PANX1

zebrafish Panx1a

zebrafish Panx1b

Gate 1

W74-R75

W74-C75

M74-R75

Gate 2

I58

V58

V58

Gate 3

T21-E22-P23

S21-E22-N23

S21-D22-S23

CBXa binding motif

I247-I258-F262

I247-V258-L262

L247-V258-V262

  1. aCarbenoxolone (CBX).
Back to article page