Fig. 4: Oral administration of M1 ameliorates glycemic parameters in db/db mice. | Communications Biology

Fig. 4: Oral administration of M1 ameliorates glycemic parameters in db/db mice.

From: An anti-diabetic drug targets NEET (CISD) proteins through destabilization of their [2Fe-2S] clusters

Fig. 4

a Percentage change (relative to predosed randomization measurements on day-3) in circulating HbA1c after 31 days treatment with 7 mg/kg (yellow) or 20 mg/kg (orange) M1 and 3 mg/kg of rosiglitazone (white). b Blood glucose levels after a 4 h fast following 28 days of treatment with 7 mg/kg (yellow) or 20 mg/kg (orange) M1 and 3 mg/kg (white) of rosiglitazone. c Mean liver fat area following histological assessment after 31 days treatment with 20 mg/kg (orange) d Body weight as a percentage of day 0 following treatment of mice with 7 mg/kg (red circle) and 20 mg/kg (orange diamond) M1, 3 mg/kg rosiglitazone (purple circle) and vehicle control (black circle). *<0.05, **P < 0.01, ***P < 0.0001. n = 10.

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