Fig. 4: Hypermethylation of CpGs that are unmethylated in non-cancer human tissues is replicated in TCGA samples for colon and rectal adenocarcinoma as well as other cancer types. | Communications Biology

Fig. 4: Hypermethylation of CpGs that are unmethylated in non-cancer human tissues is replicated in TCGA samples for colon and rectal adenocarcinoma as well as other cancer types.

From: Chromosome-specific retention of cancer-associated DNA hypermethylation following pharmacological inhibition of DNMT1

Fig. 4

Heatmaps showing DNA methylation level as measured by the 22 HCT116 GSK5032-resistant probes (rows) in (a) COAD/READ samples (columns) (n = 402 COAD/READ tumor samples, n = 41 adjacent normal samples) (b) and a panel of cancer samples other than COAD/READ from TCGA data for identified probes that were unmethylated in non-cancer human tissues. A color spectrum of blue to red indicates low to high levels of DNA methylation (β-values ranging from 0 to 1). Samples were organized first by biological sex and then tissue type (cancer/normal). Genes discussed in the main text are labeled in red. Tumor type annotation is plotted beneath each heatmap, with color code explained as ‘source’ (n = 8790 human tumor samples, n = 714 adjacent normal samples).

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