Fig. 6: Dotplots showing the results of KEGG pathways enrichment analyses performed for DE genes (either up-regulated or down-regulated) associated with exposure to a combination of anti-aging interventions (dietary restriction (DR); co-administration of berberine, fucoxanthin, and rapamycin (3G); living in constant darkness (DD) and low temperature (18 °C) conditions) in 5-day-old D. melanogaster.
a w/w males, b w/w females, c E(z)/w males, d E(z)/w females. The X-axis and dot size indicate gene ratio (the number of DEGs involved in the KEGG pathway divided by a total number of genes that are annotated as participants of this pathway). Pathways passed the FDR < 0.05 threshold are highlighted in red.
