Fig. 3: A schematic of permutation process to identify significantly mutated non-coding RNAs in breast cancer. | Communications Biology

Fig. 3: A schematic of permutation process to identify significantly mutated non-coding RNAs in breast cancer.

From: Somatic point mutations are enriched in non-coding RNAs with possible regulatory function in breast cancer

Fig. 3

To determine the significance level of mutations in ncRNAs, we calculated P values for 1,000,000 random permutations of breast/non-breast labels to estimate the 99% C.I. threshold of P values. The permutation accounts for statistical significance based upon our original data sampling and avoids Type II errors that may arise from multiple testing correction approaches such as Bonferroni. We performed the permutations for each ncRNA separately. The red color indicates the 99% C.I. of observed P values in the permutations in the figure.

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