Fig. 4: Enrichment of GWAS SNPs and eQTL polymorphisms in the significant set of ncRNAs. | Communications Biology

Fig. 4: Enrichment of GWAS SNPs and eQTL polymorphisms in the significant set of ncRNAs.

From: Somatic point mutations are enriched in non-coding RNAs with possible regulatory function in breast cancer

Fig. 4

a Enrichment of breast and lung cancer-associated GWAS SNPs in the candidate non-coding RNAs. b Enrichment of breast and lung tissues associated eQTL pairs in the candidate non-coding RNAs. We repeated the enrichment analysis with many items (e.g., GWAS SNP or eQTL polymorphisms) overlapping the ncRNAs. E.g., counting the number of ncRNAs that encompass at least 2/3/4/5/6/7/8/9/ GWAS SNPs or eQTL polymorphisms. As the figure shows, the candidate set of ncRNAs significantly enriched for both BC-related GWAS SNPs and breast tissue-related eQTL polymorphisms. This enrichment is much higher than the enrichment in lung cancer-related GWAS SNPs and lung tissue-related eQTL polymorphisms.

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