Table 2 Pathways of ANNOVAR- and distance-based differentially expressed genes associated with prostate cancer CpGs.
Gene association approach | Pathway database | Pathway | FDR |
|---|---|---|---|
ANNOVAR | BioCarta | Caspase cascade in apoptosis | 9.61 × 10−4 |
Elsevier | Lipodystrophy, familial partial | 2.03 × 10−3 | |
Familial partial lipodystrophy type 2 progression (hypothesis) | 2.82 × 10−3 | ||
Hutchinson-Gilford Progeria syndrome | 3.12 × 10−3 | ||
Nuclear lamina cleavage | 3.62 × 10−3 | ||
Nuclear envelope in cell division | 3.62 × 10−3 | ||
mTOR signalling | 3.43 × 10−2 | ||
KEGG | Glutathione metabolism | 2.90 × 10−2 | |
Reactome | Detoxification of reactive oxygen species | 2.97 × 10−2 | |
WikiPathway | The influence of laminopathies on Wnt signalling | 1.34 × 10−2 | |
The overlap between signal transduction pathways that contribute to a range of LMNA laminopathies | 2.71 × 10−2 | ||
Distance | BioCarta | Caspase cascade in apoptosis | 1.50 × 10−3 |
Elsevier | Lipodystrophy, familial partial | 3.18 × 10−3 | |
Familial partial lipodystrophy type 2 progression (hypothesis) | 4.41 × 10−3 | ||
Hutchinson-Gilford Progeria syndrome | 4.88 × 10−3 | ||
Nuclear lamina cleavage | 5.65 × 10−3 | ||
Nuclear envelope in cell division | 5.65 × 10−3 | ||
WikiPathway | The influence of laminopathies on Wnt signalling | 2.07 × 10−2 | |
The Overlap between signal transduction pathways that contribute to a range of LMNA laminopathies | 4.18 × 10−2 |
