Fig. 2: Manhattan plot for the GWAS analysis of the combined hormone-sensitive cancers in the UKB.
From: Considering hormone-sensitive cancers as a single disease in the UK biobank reveals shared aetiology
The plot shows on the Y-axis the negative log-base-10 of the P value for each of the SNPs positioned along the X axis in genomic order by chromosomal position. The red line shows the threshold for genome-wide significance (P < 5 × 10−8). SNPs with the lowest P value of significance (i.e., highest association with hormone-sensitive cancer) are positioned at the top of the graph. a The genome wide significant SNPs for all cases of hormonal cancers [incident and prevalent cases included]. b The panel is for incident cancer cases only. The list of genetic markers for each analysis is attached in the supplementary files (Supplementary Tables 7 and 8). The genomic inflation factor (λ) was rescaled for an equivalent study of 1000 cases/1000 controls (λ1000 (all cases) = 1.003 and λ1000 (incident cases) = 1.003).
