Fig. 4: Assessment of the synergistic antimicrobial effect of Ob and colistin on starvation-induced persisters of colistin-resistant and colistin-susceptible ESKAPE bacterial pathogens. | Communications Biology

Fig. 4: Assessment of the synergistic antimicrobial effect of Ob and colistin on starvation-induced persisters of colistin-resistant and colistin-susceptible ESKAPE bacterial pathogens.

From: Otilonium bromide boosts antimicrobial activities of colistin against Gram-negative pathogens and their persisters

Fig. 4

All strains had been starved for 24 h prior to treatment with various concentrations of colistin alone, Ob alone or a combination of both. a Population size of mcr-1-bearing E. coli treated with different concentrations of colistin; b population size of mcr-1-bearing E. coli treated with different concentrations of colistin and 20 µg/ml Ob; c population size of colistin-susceptible E. coli J53 treated with different concentrations of colistin; d population size of colistin-susceptible E. coli J53 treated with different concentrations of colistin and 20 µg/ml Ob; e population size of colistin-susceptible A. baumannii 17978 treated with different concentrations of colistin; f population size of colistin-susceptible A. baumannii 17978 treated with different concentrations of colistin and 10 µg/ml Ob. CT, colistin. Data are mean ± SEM for n = 3 biologically independent experiment.

Back to article page