Fig. 7: Ob dissipates the bacterial membrane potential. | Communications Biology

Fig. 7: Ob dissipates the bacterial membrane potential.

From: Otilonium bromide boosts antimicrobial activities of colistin against Gram-negative pathogens and their persisters

Fig. 7

Dissipation of membrane potential in mcr-1-bearing E. coli J53 upon treatment with Ob (a), colistin (b), and various combinations of the two drugs (c). d Comparison of effects of different compounds on the bacterial cell membrane potential of mcr-1-bearing E. coli J53. Valinomycin, a K+ ionophore, was used as positive control. The assay was conducted in the presence of 100 mM of KCl. CT, colistin. e Fluorescence microscopic images of bacterial membrane potential of mcr-1-bearing E. coli J53 taken upon treatment with Ob and colistin. Gramicidin, an ionophore, was used as the positive control. Data are mean ± SEM for n = 3 biologically independent experiment.

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