Fig. 2: More pronounced aortic stiffening at high distending pressure corresponds to increased levels of types I and III collagen. | Communications Biology

Fig. 2: More pronounced aortic stiffening at high distending pressure corresponds to increased levels of types I and III collagen.

From: Progressive aortic stiffness in aging C57Bl/6 mice displays altered contractile behaviour and extracellular matrix changes

Fig. 2

Peterson modulus expressed in function of age for increasing distending pressure from 60–100, 80–120, 100–140, to 120–160 mmHg (a). Values of slope from linear regression analysis are listed on the right for each pressure. Histological assessment of area positivity for type I and II collagen (b, c). Data are listed as mean ± SEM (n > 8) (a) or each symbol represents an individual biological repeat (n = 5) (b, c). Statistical analysis using two-way ANOVA (a) or one-way ANOVA (b, c). Overall significance (bottom of graph) and post hoc significance vs. 4-month value (in graph) are listed. *p < 0.05, **p < 0.01, ***p < 0.001.

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