Fig. 7: Effects of OI on the expression of cartilage degradation-related proteins, apoptosis-related proteins and autophagy-related proteins in OA rats. | Communications Biology

Fig. 7: Effects of OI on the expression of cartilage degradation-related proteins, apoptosis-related proteins and autophagy-related proteins in OA rats.

From: Four-octyl itaconate improves osteoarthritis by enhancing autophagy in chondrocytes via PI3K/AKT/mTOR signalling pathway inhibition

Fig. 7

a The expression levels of MMP3, MMP13, BAX, pro-caspase3, cleaved caspase3, LC3, Beclin-1, p62, and GAPDH in rats were determined by western blotting and b–h normalised to that of GAPDH (n = 3). The error bar is SD. The data are the mean ± SD. *P < 0.05, **P < 0.01, ***P < 0.001.

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