Fig. 5: Conservation of the Guanine binding pocket in human coronaviruses.
From: Identification of a guanine-specific pocket in the protein N of SARS-CoV-2
Cartoon representation of the GTP binding pocket in SARS-CoV-2 (a), SARS-CoV-1 (PDB 2GIB) (b), MERS (PDB 6G13) (c) and NL63 (PDB 5EPW) (d). Each monomer of the dimer is represented in different colors. The residues that mediate the GTP binding in SARS-CoV-2 and equivalent residues in other coronaviruses are shown in sticks with carbons in the same color as the monomer to which they belong. The GTP molecule is represented in semi-transparent sticks with carbon atoms in green. The trimethylamine oxide (TMO) bound to MERS is shown in sticks with carbons in cyan. e Sequence alignment of NCTD of human coronaviruses. Invariant residues are in bold and indicated with an asterisk above the sequence. Residues for the GTP binding are in bold and highlighted in blue, and conservative changes are in light green. Secondary structural elements of the SARS-CoV-2 NCTD are represented below the sequence and labeled and numbered from N to C. η corresponds to 310 helices; α to α-helices and β to β-strands.
