Table 1 Local genetic correlations between cerebellar volume and disease.

From: Genome-wide association study of cerebellar volume provides insights into heritable mechanisms underlying brain development and mental health

Trait

Locus

Local rg

P value

Local h2shared

Chromosome

Start

End

PD

14

67,991,028

69,355,606

−1.31

1.83 × 10−6

−3.71 × 10−4

AD

16

29,694,822

31,380,596

0.98

4.73 × 10−8

3.72 × 10−4

NDG

16

29,694,822

31,380,596

0.91

1.36 × 10−8

4.02 × 10−4

SCZ

12

121,721,831

124,710,880

0.89

1.58 × 10−11

2.43 × 10−3

19

18,506,815

19,873,269

−1.03

2.77 × 10−6

−6.81 × 10−4

NDV

12

121,721,831

124,710,880

0.83

2.78 × 10−7

1.29 × 10−3

19

18,506,815

19,873,269

−1.09

7.16 × 10−7

−6.89 × 10−4

  1. Local genetic correlations (rg) (Bonferroni-corrected α = 3.18 × 10−6) between cerebellar volume and PD = Parkinson’s disease, AD = Alzheimer’s disease, SCZ = schizophrenia, NDV = meta-analysis of neurodevelopmental disorders (ASD, ADHD, SCZ), NDG = meta-analysis of neurodegenerative disorders (AD,PD). Local shared SNP-heritability was calculated as \({h}_{{shared}}^{2}=\,{{local}r}_{g}* \sqrt{{{local}\,h}_{{trait}\,1}^{2}* {{local}\,h}_{{trait}\,2}^{2}}\).
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