Fig. 1: Bivalent particle formation upon admixture of CSP and Pfs230D1+ with CoPoP liposomes. | Communications Biology

Fig. 1: Bivalent particle formation upon admixture of CSP and Pfs230D1+ with CoPoP liposomes.

From: Vaccine co-display of CSP and Pfs230 on liposomes targeting two Plasmodium falciparum differentiation stages

Fig. 1

a Schematic representation of the bivalent CoPoP liposomes displaying Pfs230D1+ (“230”) and full-length P. falciparum CSP (“CSP”). b Antigen binding to CP liposomes was measured by Ni-NTA bead competition assay. Identical PoP liposomes lacking cobalt served as a control. c Binding percentage of antigens to CoPoP or PoP liposomes using a mass ratio of [CoPoP or PoP: CSP: 230] = 4:1:0.5. d Particle size before and after antigen binding. Bars show mean ± s.d for n = 3-5 replicates. Red bars indicate bivalent, liposome-displayed CSP/230.

Back to article page