Fig. 1: Proton-induced currents (IH(β)) through homomeric GABAA β1(S265N), β2 and β3 receptors induced at a holding potential of -70 mV from pH of 9. | Communications Biology

Fig. 1: Proton-induced currents (IH(β)) through homomeric GABAA β1(S265N), β2 and β3 receptors induced at a holding potential of -70 mV from pH of 9.

From: β subunits of GABAA receptors form proton-gated chloride channels: Insights into the molecular basis

Fig. 1

a, c Representative IH(β) through β3 (human, rat), β1 and β2 subunit homomers elicited by rapidly switching the pH from 9 to the indicated values. b, d Normalized pH-response curve of IH(β) through β3hum (pH50 = 6.09 ± 0.2, nH = 1.25 ± 0.37), β3rat (pH50 = 6.1 ± 0.01, nH = 1.25 ± 0.08), β2 (pH50 = 6.23 ± 0.13, nH = 1.07 ± 0.05) and β1(S265N) (pH50 = 6.03 ± 0.1, nH = 1.45 ± 0.21) homomers. The data are presented as mean values ±SEM, n = 5. The insets in (b) illustrate block of baseline current (left) and inhibition of IH(β) (right).

Back to article page