Fig. 5: Protonation of H267 effects pore features as well as Cl- occupancy.
From: β subunits of GABAA receptors form proton-gated chloride channels: Insights into the molecular basis
Cl− density, hydrophobicity of the pore-facing residues and radius of the pore calculated by the channel annotation programme (CHAP67). Right: Pore of β3 GABAAR as detected by CHAP. Black dotted lines indicate the projection of the property curves on the pore. Pore properties on the left are the averaged over 2 µs MD simulation of β3 GABAAR with H267 protonated and deprotonated β3 GABAAR.
