Fig. 2: hSMOX crystallography construct design.
From: Structure of human spermine oxidase in complex with a highly selective allosteric inhibitor
a Ribbon structure representation in green of mPAOX (PDB ID:5LEA) on the left and dynamic properties of hSMOX analyzed by HDX-MS on the right. The relative deuterium uptake illustrating the local dynamics of different structural units is depicted on hSMOX model using a color code from blue (1% deuterium uptake, protected) to red (100% deuterium uptake; disordered/flexible). b Front and back of engineered hSMOX with key modifications depicted and color-coded. c Construct modifications for each design stage depicted on ribbon hSMOX model structure and color-coded.
