Fig. 1: Antibody binding to the RBD of wild type and SARS-CoV-2 VOCs by ELISA. | Communications Biology

Fig. 1: Antibody binding to the RBD of wild type and SARS-CoV-2 VOCs by ELISA.

From: Conformational flexibility in neutralization of SARS-CoV-2 by naturally elicited anti-SARS-CoV-2 antibodies

Fig. 1

ACE2bs or non-ACE2bs antibodies are indicated to the left of each panel, a–d. For panels a–c, each graph represents antibody binding to wild type or VOC (a), single (b) or double (c) mutant RBD. AUC was calculated by GraphPad Prism. The raw OD650 values, as well as isotype control, are presented in Supplementary Fig. 1. Each experiment was repeated at least three times (n ≥ 3). d Summary of the antibody binding affinity to each RBD generated in this study. Green color indicates binding affinity of >75%, orange of 25–75%, and yellow of <25% as compared to wild type RBD. The VOCs harboring each mutation are indicated.

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