Fig. 3: The interplay between neuroinflammation with the BOLD response at a task-driven functionally defined PCC cluster. | Communications Biology

Fig. 3: The interplay between neuroinflammation with the BOLD response at a task-driven functionally defined PCC cluster.

From: Dual PET-fMRI reveals a link between neuroinflammation, amyloid binding and compensatory task-related brain activity in Alzheimer’s disease

Fig. 3: The interplay between neuroinflammation with the BOLD response at a task-driven functionally defined PCC cluster.The alternative text for this image may have been generated using AI.

a PCC cluster (left hemisphere; center of mass in TAL space: −9.70, −55.44, 26.77; center of mass in MNI space: −9.16, −54.27, 31.2) extracted from the functional contrast [scrambledAD > scrambledcontrols]. b Relationship between the extension of neuroinflamation at the PCC cluster, quantified by the 11C-PK11195 BPND, and the scrambled stimulus betas on that region. Higher betas express higher neuronal activation.

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