Fig. 1: Some of the major mechanisms of action of mitochondrial toxicants. | Communications Biology

Fig. 1: Some of the major mechanisms of action of mitochondrial toxicants.

From: Integrating cell morphology with gene expression and chemical structure to aid mitochondrial toxicity detection

Fig. 1: Some of the major mechanisms of action of mitochondrial toxicants.

Toxicants act on multiple pathways to exhibit mitochondrial toxicity, including but not limited to, unfolded protein response, inhibition of mitochondrial respiratory chain or uncoupling of oxidative phosphorylation, oxidative stress from responses including generation of reactive oxygen species (ROS), microtubule disruption and ER stress from various responses including inhibition of Na+ pumps etc. The Figure was partly generated using Servier Medical Art, provided by Servier, licensed under a Creative Commons Attribution 3.0 unported license.

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