Fig. 2: ADNI Polygenic Risk Scores using Lambert et al., 2013 GWA Summary Statistics. | Communications Biology

Fig. 2: ADNI Polygenic Risk Scores using Lambert et al., 2013 GWA Summary Statistics.

From: The Polygenic Risk Score Knowledge Base offers a centralized online repository for calculating and contextualizing polygenic risk scores

Fig. 2: ADNI Polygenic Risk Scores using Lambert et al., 2013 GWA Summary Statistics.The alternative text for this image may have been generated using AI.

PRSice-2 (dark grey), and the PRSKB (light grey) scores are shown. a PRSice-2 reports polygenic risk scores that center on 0, so 1.0 was added to each PRSice-2 score to put it on the same scale as the PRSKB, which centers polygenic risk scores based on odds ratios around 1.0. The PRSice-2 median score after transformation is 1.05207 and the PRSKB median score is 1.05338. b Since a polygenic risk score is a relative score compared to the sample population, we transformed the PRSKB scores by subtracting 0.00131 to overlap the shape of the distributions when both algorithms report the same median. Since the scores are normally distributed, a Welch’s two-sample t-test was used to determine the similarity between the two distributions, which were nearly identical (t = 0.004782; P = 0.9962).

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