Fig. 6: Nementin structure-activity relationship analysis.

a The analog structures are represented by the Markush structure at the top and includes atom and substituent identifiers. b Data for the free-living nematodes are EC50s (µM) and color-coded based on the potency scale at the bottom of this section. EC50s are generated from tests of a concentration series over n = 3 biologically independent trials. c, d Nematode parasites of mammals or plants were tested with a limited number of compound concentrations. In each cell in these sections, the lowest concentration (µM) tested that exhibited a phenotype is shown, and the percentage of animals that exhibit the phenotype is indicated by the color scale at the bottom of this section. e Data for models of non-targeted systems is reported either as an EC50 (µM) (for the HEK293 cells) or as the lowest concentration tested (µM) that exhibited a discernible phenotype compared to wild-type at the indicated concentration; the percentage of animals that exhibit the phenotype is indicated by the color scale at the bottom of this section. np no phenotype (<20% effect), nt not tested. See the Methods for a description of each assay. Primary data for this figure can be found in Supplementary Data 6.