Fig. 6: PEDF levels in ascites fluid and serum samples are increased in OC patients. | Communications Biology

Fig. 6: PEDF levels in ascites fluid and serum samples are increased in OC patients.

From: Pigment epithelium-derived factor promotes peritoneal dissemination of ovarian cancer through induction of immunosuppressive macrophages

Fig. 6

a Pearson’s correlation analysis for expression of SERPINF1 versus that of IL10, CD163, MSR1, TGFB1, IL12A, or NOS2 in human OC samples of TCGA (n = 531). b PEDF concentration as measured with an ELISA in ascites specimens of patients with LMP ovarian tumors (n = 3) or OC (n = 28). c Concentration of IL-10 in ascites samples of patients with LMP tumors (n = 3) or OC (n = 28) as measured with an ELISA. d Pearson’s correlation analysis for IL-10 and PEDF concentrations in ascites specimens of patients with OC (n = 28). e Serum PEDF concentration of patients with benign ovarian tumors (n = 6), LMP tumors (n = 15), or OC (n = 46) as measured with an ELISA. Data are means ± SD and were analyzed by Welch’s ANOVA followed by Dunnett’s post hoc test. Data for b, c are means ± SD and were analyzed by unpaired t test with Welch’s correction.

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