Fig. 2: Multimodal imaging corroborates the finding that the RPE cells are enlarged in choroideremia. | Communications Biology

Fig. 2: Multimodal imaging corroborates the finding that the RPE cells are enlarged in choroideremia.

From: Widespread subclinical cellular changes revealed across a neural-epithelial-vascular complex in choroideremia using adaptive optics

Fig. 2: Multimodal imaging corroborates the finding that the RPE cells are enlarged in choroideremia.

Co-registered adaptive optics optical coherence tomography (AO-OCT) images and (AO-ICG) images from choroideremia are shown in comparison to healthy examples. a–h RPE cells from both affected males and female carriers are enlarged compared to (i–l) healthy RPE cells. Green circles are examples of individual RPE cells from each pair of images. RPE cell nuclei can be seen as the small dark spots in AO-OCT images (e.g., white arrows). The increased spacing between cell nuclei in choroideremia compared to healthy eyes can be seen in the AO-OCT images. The retinal locations (eccentricities) of the images are (a, b) 1.0 mm, (c, d) 1.5 mm, (e–h) 0.5 mm, (i, j) 0.5 mm, and (k, l) 1.5 mm. Scale bar, 50 µm.

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