Fig. 4: Univariate and multivariate analyses with respect to age-related GMV changes.

a Results displaying the overlap between pipelines at a cluster-level p_FWE < 0.05 with initial cluster forming voxel level p < 0.001. The left panels of a depict brain regions with increasing GMV with age. The right panels of a depict decreases with age. For a and d the pipelines are coded as: red = CAT, green = FSLVBM, blue = FSLANAT, light blue = sMRIPrep, additional colors visualize the overlap between the results, e.g., CAT ∩ FSLVBM = yellow, CAT ∩ FSLANAT = purple, FSLVBM ∩ FSLANAT = light blue, CAT ∩ FSLVBM ∩ FSLANAT = white and etc. b The variability of unthresholded statistical maps. The correlation values between whole-brain unthresholded statistical maps of four pipelines were computed, respectively, for age-related effects. Only positive values are visualized for display purpose. c Reliable brain patterns to predict age determined by bootstrapping tests (5000 permutations, p_FDR < 0.05), and d cross-predicted r value of four pipelines for each of the pipeline proprocessed samples. The color from cold to warm indicates increasing r values (from 0.8 to 1).