Fig. 3: Adult-offspring hepatic gene expression profiles. | Communications Biology

Fig. 3: Adult-offspring hepatic gene expression profiles.

From: Paternal low protein diet perturbs inter-generational metabolic homeostasis in a tissue-specific manner in mice

Fig. 3

Analysis of adult (16 weeks) F1 offspring hepatic transcript profiles with a Venn diagram displaying number of genes with differential expression (>1.5 fold, either positive or negative) between adult (16 weeks of age) NN (NPD sperm and NPD seminal plasma), LL (LPD sperm and LPD seminal plasma), NL (NPD sperm and LPD seminal plasma) and LN (LPD sperm and NPD seminal plasma) offspring liver. Volcano plot of differential genes (>1.5 fold, either positive or negative) between b NN and LL adult offspring, c NN and NL offspring and d NN and LN offspring. e Venn diagram displaying number of genes with differential expression (>1.5 fold, either positive or negative) between adult (16 weeks of age) NN (NPD sperm and LPD seminal plasma), LL (LPD sperm and LPD seminal plasma), NL (NPD sperm and LPD seminal plasma) and LN (LPD sperm and NPD seminal plasma) female offspring liver. Volcano plot of differential genes (>1.5 fold, either positive or negative) between f NN and LL adult females, g NN and NL adult females and h NN and LN adult females. i Venn diagram displaying number of genes with differential expression (>1.5 fold, either positive or negative) between adult (16 weeks of age) NN (NPD sperm and LPD seminal plasma), LL (LPD sperm and LPD seminal plasma), NL (NPD sperm and LPD seminal plasma) and LN (LPD sperm and NPD seminal plasma) male offspring liver. Volcano plot of differential genes (>1.5 fold, either positive or negative) between j NN and LL adult males, k NN and NL adult males and l NN and LN adult males. N = 4 males and 4 females, each from separate litters. Statistical differences were determined by one-way ANOVA with Partek® Genomics Suite® analysis software.

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