Fig. 5: Assessment of second-generation (F2) offspring lipid profiles. | Communications Biology

Fig. 5: Assessment of second-generation (F2) offspring lipid profiles.

From: Paternal low protein diet perturbs inter-generational metabolic homeostasis in a tissue-specific manner in mice

Fig. 5

a Body weight and b liver weight of NN (NPD sperm and NPD seminal plasma), LL (LPD sperm and LPD seminal plasma), NL (NPD sperm and LPD seminal plasma) and LN (LPD sperm and NPD seminal plasma) F2 offspring at 3 weeks of age. Relative c hepatic and d serum abundance of saturated (Sat) mono-unsaturated (Mono) and poly-unsaturated (Poly) lipids. e Z scores of differential lipids between NN, LL, NL and LN offspring in e liver tissue and f serum. Cer ceramide, DG diglyceride (water-loss product from fragmentation in source), LPC lyso-phosphatidylcholine, LPE lyso-phosphatidylethanolamine, LPG lyso-phosphatidylglycerol, PA phosphatidic acid, PC phosphatidylcholine, PC-P phosphatidylcholine plasminogen, PC-O phosphatidylcholine plasmalogen, PE phosphatidylethanolamine, PI phosphatidylinositol, SM sphingomyelin, TG triglyceride, TGox oxidised triglyceride. Differential serum lipids in g male and h female offspring. N = 5–10 males and females per treatment group, selected from all litters generated. ∗p < 0.05. Statistical differences were determined using one-way ANOVA with Bonferoni post hoc correction.

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