Fig. 2: IDH2 deficiency upregulates fatty acid and cholesterol synthesis. | Communications Biology

Fig. 2: IDH2 deficiency upregulates fatty acid and cholesterol synthesis.

From: miR204 potentially promotes non-alcoholic fatty liver disease by inhibition of cpt1a in mouse hepatocytes

Fig. 2

a Mechanisms of fatty acid and cholesterol synthesis. b, c Citrate and acetyl-CoA levels in liver tissue determined using a colorimetric/fluorometric assay kit. d, e Expression of genes related to cholesterol efflux and synthesis, and fatty acid synthesis and β-oxidation, revealed by quantitative real-time PCR (normalized to GAPDH). Data are means ± SEM of three independent experiments (n = 3). *p < 0.05 vs. WT-ND mice. #p < 0.05 vs. WT-HFD mice.

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