Fig. 7: Colocalization of eQTLs across humans and cattle.
From: The conservation of human functional variants and their effects across livestock species
a The human gene neighborhood (hg38) of a shared eQTL, rs115287948, found across both humans and cattle. The gene regulated by the eQTL is indicated by a purple rectangle. b Strength of association of human variants with SIRPB1 expression levels in cultured fibroblasts tissue. The fine-mapped regulatory variant, rs115287948, with a cattle orthologue is represented by the purple diamond. Other variants are colored according to their linkage disequilibrium (\({r}^{2}\)) with this variant. c Strength of association of the same human variants but in muscle tissue. d Strength of association of variants with SIRPB1 in cattle muscle tissue (mixed breeds). Each variant is plotted according to their orthologous position in the human genome and the variant with a fine-mapped orthologue in the human GTEx data is represented by the purple diamond. e–g same as a, b, d but for variant rs2230126 linked to the expression of TAF1C in different tissues. The data underlying this figure can be found in Supplementary Data 7.
