Fig. 1: Heritability enrichment of 28 human complex traits in the Cas-enriched genomic regions.
From: Contribution of CRISPRable DNA to human complex traits
The heatmap shows the heritability enrichment of Cas annotations on 28 traits. Traits are categorized into five domains and their names are in different colors. The barplot right to the heatmap shows the SNP base heritability estimated by LDSC. The two bar plots on top of the heatmap show the overall GC content (top) and average heritability enrichment (bottom) for n = 21 Cas enzymes, respectively. *Indicates significance after multiple testing correction with a false discovery rate of 0.05.
