Fig. 2: Cryo-EM structure of the 11-2F-bound PRMT5:MEP50 complex. | Communications Biology

Fig. 2: Cryo-EM structure of the 11-2F-bound PRMT5:MEP50 complex.

From: Cryo-EM structure-based selection of computed ligand poses enables design of MTA-synergic PRMT5 inhibitors of better potency

Fig. 2

a A 3.1 Å cryo-EM map of the complex in two different orientations with the atomic model built in the density (PRMT5 in pink and MEP50 in red). b Local resolution variations of the map estimated by ResMap. c Comparison of the cryo-EM model (green PRMT5 and yellow MEP50) with the X-ray structure (orange; PDB: 6CKC). d Matching of the side chains in two short helices of the cryo-EM model with the density (blue mesh). e Densities for MTA and 11-2F are well defined in the cryo-EM map. The MTA tail is right next to the quinoline part of 11-2F. The models of the protein and the inhibitor are in pink.

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