Fig. 4: pSMAD2high/SMAD4- pancreatic tumors are correlated with increased aggressiveness in vivo. | Communications Biology

Fig. 4: pSMAD2high/SMAD4- pancreatic tumors are correlated with increased aggressiveness in vivo.

From: SMAD2/3 mediate oncogenic effects of TGF-β in the absence of SMAD4

Fig. 4: pSMAD2high/SMAD4- pancreatic tumors are correlated with increased aggressiveness in vivo.

a Immunohistochemistry for SMAD4 and pSMAD2 on 506 clinically annotated resected primary human PDAC. The tumors were separated into four groups according to SMAD4 and pSMAD2 status (SMAD4+/pSMAD2high, SMAD4+/pSMAD2low, SMAD4-/pSMAD2high, SMAD4-/pSMAD2low). b Survival curve of patients with SMAD4-/pSMAD2high PDAC compared to pooled three other groups. c Univariate analysis of the correlation between the SMAD4-/pSMAD2high tumor pattern and aggressiveness/histopathological features. d Multivariate SMAD4-/pSMAD2high pattern correlation analysis. e pT and pN status distribution for SMAD4-/pSMAD2high tumors and non-SMAD4-/pSMAD2high tumors.

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