Fig. 8: Schematic representation of signaling pathways regulated by Probio-M9 feeding in C. elegans. | Communications Biology

Fig. 8: Schematic representation of signaling pathways regulated by Probio-M9 feeding in C. elegans.

From: Lacticaseibacillus rhamnosus Probio-M9 extends the lifespan of Caenorhabditis elegans

Fig. 8

Live Probio-M9 feeding increases the lifespan of worms via the Insulin/IGF-1 signaling (DAF-2/SKN-1) and p38 MAPK signaling (NSY-1–SEK-1–PMK-1) pathways. It also triggers mitochondrial unfolded protein response (UPRmt) to maintain mitochondrial homeostasis. Therefore, Probio-M9 feeding extends the lifespan of C. elegans by improving the stress resistance, activating defensive system, and enhancing UPRmt.

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