Fig. 7: A structural model of the human Otop1 channel.
From: The roles of two extracellular loops in proton sensing and permeation in human Otop1 proton channel
The structure was built with the deep learning method RoseTTAFold32. a The side (left) and top (right) views of the model, show the positions of the L5–6 (green) and L11–S12 (purple). The first 1/3 of the putative L5–6 was predicted to be an extension of the S5 helix. Side chains of H229 (orange) and D570 (blue) are shown as spheres. The three putative pores are indicated by dotted orange ellipses. NTT N-terminal tail. b An enlarged view to show the predicted interactions between H229 and F580, and between H229 and E575. R232 is also shown here. It is predicted to point to the pore formed at the intracellular interface. c Cartoon showing the possible initiation of proton permeation at the extracellular side of the C pore.
