Table 1 Anergic B cells lacking NDGR1 survive and compete normally in a polyclonal repertoire.

From: NDRG1 is induced by antigen-receptor signaling but dispensable for B and T cell self-tolerance

Tissue

BM (×106)

Spleen (×106)

Recipient

Non-tg

sHEL

Non-tg

sHEL

BM donor

WT IgHEL

Ndrg1−/− IgHEL

WT IgHEL

Ndrg1−/− IgHEL

WT IgHEL

Ndrg1−/− IgHEL

WT IgHEL

Ndrg1−/− IgHEL

Total B

5.86 (1.8)

8.49 (2.5)

8.27 (3.9)

9.17 (1.9)

42.31 (10.9)

71.49 (18.5)

40.95 (14.06)

63.22 (28.1)

IgHEL

2.67 (0.8)

3.45 (1.0)

3.48 (1.7)

3.09 (0.9)

6.56 (3.7)

9.06 (4.3)

4.32 (2.3)

2.82 (1.4)

  1. Numbers of total B220+ (Total B) and HyHEL9+CD45.1− B220+ (IgHEL) cells in the BM and spleen of Non-tg or sHEL recipients reconstituted with 80% WT or Ndrg1−/− IgHEL CD45.2+ BM and 20% non-transgenic polyclonal WT CD45.1+ BM cells. Data reported are means (and SD) from one experiment, with 4–6 mice per group.
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