Fig. 6: Slit lamp evaluation of treated vs. untreated eyes at 12 months.
From: Prostaglandin-based rAAV-mediated glaucoma gene therapy in Brown Norway rats
Slit lamp examination photographs graded by 5 masked participants were compared between untreated and treated eyes for each dosage group for cell (a–c), flare (d–f), and iris pigment dispersion (g–i). A Fisher’s exact test revealed that in the case of low dose cell (a), cell presence was dependent on vector administration, but not for medium or high dosage groups (b, c). In all cases of flare, the Fisher’s exact test revealed that flare score is independent of vector administration (d–f). Similarly, all dosage groups exhibited increased iris exfoliation that was dependent on vector administration (g–i). (Fisher’s exact test: p-values= 0.0165 (a), 0.7516 (b), 0.1099 (c), 0.0952 (d), 0.3938 (e), 0.2451 (f), 0.0011 (g), 0.002 (h), and <0.001 (i). N = 9, 7, and 5 for low, medium, and high dose respectively).
