Fig. 6: Comparison of PAK4 complexes.
From: Molecular basis for integrin adhesion receptor binding to p21-activated kinase 4 (PAK4)
Superposition of PAK4 structures in complex with integrin β5 (7S46, 7S47, and 7S48), consensus peptide (2Q0N), PAKtide-S (4JDI)47, autoinhibitory pseudosubstrate (4FII)25, N-terminal polybasic region (5UPK)27, (Inka inhibitory pseudosubstrate (4XBU)30, LIMK1 substrate peptide (6WLY)48 and β-catenin substrate peptide (6WLX)48. a Electrostatic surface of PAKtide-S bound PAK4, sticks for bound AMP-PNP, and stick format peptides for each structure, when kinase domains are superposed on their C-lobes. b Close-up of the peptides, illustrating the similarity of location for the basic charged arginine residues. Phosphoacceptor site indicated as P-0.
