Fig. 1: Clinical history of acute EBOV infection and uveitis. | Communications Biology

Fig. 1: Clinical history of acute EBOV infection and uveitis.

From: Persistent intraocular Ebola virus RNA is associated with severe uveitis in a convalescent rhesus monkey

Fig. 1: Clinical history of acute EBOV infection and uveitis.The alternative text for this image may have been generated using AI.

a Complete timeline starting with baseline (BL) assessment and ending at necropsy on day 99. Presence of ocular clinical signs and collection of aqueous humor through anterior chamber paracentesis are indicated with dots that are called out with indicator lines. EBOV GP genome equivalents (GEq) in sera, determined by RT-qPCR (red triangles), along with rhesus monkey-specific anti-EBOV GP IgG antibodies in serum detected by ELISA (orange dots). LOD, limit of detection of assay. b Clinical euthanasia scores recorded via cageside observation. Therapeutic human monoclonal antibody 1C3 dosing schedule is indicated with arrows. c Concentrations of aspartate aminotransferase (AST) and platelet counts determined in blood are shown over time. d Edema, eyelid splinting, anterior chamber fibrin clot, and iris vessel dilation visible from day 21 through day 30. e Photographs of the right (OD) and left (OS) eyes, documenting vitreous haze OS with improvement over time. f Precontrast and post-contrast magnetic resonance (MR) images of the globes. Volumetric measurements of both eyes extrapolated from MR scans show decreased eye volume OS, suggestive of hypotony. D; day.

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