Fig. 1: Female-specific preoptic neurons express multiple neuropeptides in an ovarian-dependent manner. | Communications Biology

Fig. 1: Female-specific preoptic neurons express multiple neuropeptides in an ovarian-dependent manner.

From: Prostaglandin E2 receptor Ptger4b regulates female-specific peptidergic neurons and female sexual receptivity in medaka

Fig. 1: Female-specific preoptic neurons express multiple neuropeptides in an ovarian-dependent manner.

a Integrative genomics viewer (IGV) images of RNA-seq reads from female-specific npba-expressing neurons in the PMm/PMg of intact, sham-operated (sham), and ovariectomized (OVX) females (n = 3 for each treatment) for XLOC_022840 (cartpt2b), XLOC_003385 (tac1), and XLOC_024729 (tac4a). Phylogenetic trees showing the relationship of medaka Cartpt2b (b) and Tac1/Tac4 (c) to other known CARTPT and tachykinin family proteins. The number at each node indicates bootstrap values for 1000 replicates. Scale bar represents 0.1 substitutions per site. For species names and GenBank accession numbers, see Supplementary Table 1. d Representative micrographs showing the expression of catrpt2b, tac1, and tac4 in npba-expressing neurons in the PMm (upper panels) and PMg (lower panels). Left and middle panels show images of, respectively, cartpt2b/tac1/tac4a (magenta) and npba (green) expression in the same section; right panels show the merged images with nuclear counterstaining (blue). Arrowheads indicate representative neurons co-expressing cartpt2b/tac1/tac4a and npba. Scale bars represent 20 μm.

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