Fig. 3: Identification of enriched markers for BM LLPC in NHP. | Communications Biology

Fig. 3: Identification of enriched markers for BM LLPC in NHP.

From: Single cell multi-omic reference atlases of non-human primate immune tissues reveals CD102 as a biomarker for long-lived plasma cells

Fig. 3

a UMAP visualization of cells from NHP BM depicting results of unbiased clustering and cell type annotation. b mRNA expression in LLPC in NHP of previously identified LLPC markers in mice and humans. c Expression of surface protein markers on LLPC in NHP of previously identified LLPC markers in mice and humans. d Differential gene expression analysis for LLPC in NHP compared to all other cells isolated. Genes are ranked by expression (log fold-change; logFC) and classification power (AUROC; auc). Top 5 genes are labeled. Ensembl gene identifiers were changed to closest human homolog for the following RNA transcripts to enable ease of interpretation: ENSMMUG00000002764: human homolog IGHA1/IGHA2, ENSMMUG00000015202: human homolog IGHG1/IGHG2/IGHG3/IGHG4, ENSMMUG00000044861: human homolog IGLC1/IGLC2/IGLC3/IGLC7/IGLL5. e Differential surface protein marker expression analysis for PC in NHP compared to all other cells isolated. Surface protein markers are ranked by expression (log fold-change; logFC) and classification power (AUROC; auc). Top 5 markers are labeled.

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