Fig. 1: Persistence of humoral and cellular response in CP cohort.
From: Clonal diversity predicts persistence of SARS-CoV-2 epitope-specific T-cell response
a Levels of anti-RBD IgG as measured by ELISA at the two time-points. Means of two independent measurements are plotted. Upper plot shows samples from the same donor, connected by lines. Lower plot shows median, whiskers show interquartile range (paired Wilcoxon test); b magnitude of T-cell response to pools of peptides derived from S (green), M (red), and N proteins (blue) as measured by IFNγ ELISpot. Means of two independent measurements with negative control subtracted are plotted. Plots are presented as in a. Dotted lines in a and b mark cut-offs, the number and share of individuals without detectable response is indicated. N = 50 for both a and b; c distribution of immune responses in CPs. Colors indicate T-cell response to 0–3 peptide pools; RBD IgG+ and RBD IgG- respectively indicate the presence and absence of anti-RBD IgG; d Spearman correlation between humoral and cellular responses to different SARS-CoV-2 antigens. *p ≤ 0.05; **p ≤ 0.01; ***p ≤ 0.001; ****p ≤ 0.0001.
