Fig. 2: Diversity of the vascular smooth muscle cells (VSMCs) in proximal adjacent (PA) and calcified atherosclerotic core (AC) portions of plaques. | Communications Biology

Fig. 2: Diversity of the vascular smooth muscle cells (VSMCs) in proximal adjacent (PA) and calcified atherosclerotic core (AC) portions of plaques.

From: Macrophages regulate vascular smooth muscle cell function during atherosclerosis progression through IL-1β/STAT3 signaling

Fig. 2: Diversity of the vascular smooth muscle cells (VSMCs) in proximal adjacent (PA) and calcified atherosclerotic core (AC) portions of plaques.

UMAP clustering plots revealing a 5 color-coded cell clusters, b different groups, and c 4 cell population of a total of 7053 individual cells based on gene expression. d. Heatmap of marker genes in different VSMC subsets per among clusters. e Dot plot of cluster-identifying marker genes in VSMCs. f. Top Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways of differently expressed genes (adj.P value < 0.05 and |avg_log2FC| > 0.25) in macrophage-like VSMCs compared with other VSMC subsets. g. Volcano plot shows the differently expressed genes in VSMCs determined that were upregulated in PA or AC group (P value < 0.01 and |avg_log2FC| > 0.25).

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