Fig. 4: Transcription factors (TFs) involved in macrophage-like vascular smooth muscle cell (VSMC) differentiation. | Communications Biology

Fig. 4: Transcription factors (TFs) involved in macrophage-like vascular smooth muscle cell (VSMC) differentiation.

From: Macrophages regulate vascular smooth muscle cell function during atherosclerosis progression through IL-1β/STAT3 signaling

Fig. 4: Transcription factors (TFs) involved in macrophage-like vascular smooth muscle cell (VSMC) differentiation.

a Heatmap of macrophage-like VSMC related TFs activities (n = 127) among different VSMC subtypes. b The macrophage-like associated and differentially expressed TFs were identified as the intersection of differential expression in macrophage-like VSMC and dysregulation in different atherosclerotic groups. c Heatmap of macrophage-like associated and differentially expressed TFs activities (n = 52). The top rows represent the transcriptome signature of macrophage-like VSMCs that refer to different state of Monocle and atherosclerotic group (PA and AC). d Boxplots of the 4 signature TFs (JUN, SMAD3, CBX2, and ZEB2) that upregulated or downregulated in macrophage-like VSMCs and dysregulated between proximal adjacent (PA) and atherosclerotic core (AC) group. e Network showing 52 selected activated (red large diamonds) and repressed (blue large diamonds) TFs in AC group and their target genes (light blue small dots).

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