Fig. 6: The relationship between IL-1β and STAT3 in macrophage-to-macrophage-like VSMC interactions. | Communications Biology

Fig. 6: The relationship between IL-1β and STAT3 in macrophage-to-macrophage-like VSMC interactions.

From: Macrophages regulate vascular smooth muscle cell function during atherosclerosis progression through IL-1β/STAT3 signaling

Fig. 6

a Schematic illustrating the alterations of upstream top-ranked ligands and target transcription factors in macrophage-like vascular smooth muscle cells (VSMCs) in atherosclerotic core (AC) group. b. Linear regression plot of IL-1β with STAT3 in GSE43292 (correlation coefficient = −0.43, P value = 0.000355). Box plots show the differences in expression of IL-1β (P value = 0.002) (c) and STAT3 (P value = 0.007) (d) between macroscopically intact and atheroma plaque tissue group. e The correlation of IL-1β and STAT3 with the proportions of the 22 immune cell type through CIBERSORT algorithm (red means positive correlation, while blue means negative correlation). Correlation analysis was examined by Pearson test; for two groups, data were compared by paired t-test, n = 32 samples per group. The expressions were plotted along with group mean ± SE in boxplots.

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