Table 1 The top five Fst signals of high differentiation within each of six population comparisons are reported here.

From: Population genomics reveal distinct and diverging populations of An. minimus in Cambodia

Population comparison	Contig	Signal Position (Mbp)	Fst Value	Candidate genes in region	Gene(s)	Gene functions
RK1 v RK2	KB663622	1.3	0.54	UDP-glucuronosyltransferase	AMIN004611	Pyrethroid resistance, detoxification
RK1 v RK2	KB663622	2.3	0.52	Metalloendopeptidase, aminopeptidase N	AMIN004703, AMIN004700, AMIN004701	Pyrethroid resistance, decreased susceptibility to BT toxin
RK1 v RK2	KB664266	6	0.49	Ecdysteroid UDP-glucosyltransferase	AMIN009683	Pyrethroid resistance
RK1 v RK2	KB663832	5.7	0.49	histone acetyltransferase, α-tubulin, CHK domain-containing protein	AMIN016061, AMIN000390, AMIN000391	Dieldrin resistance, organophosphate interactions, mitochondrial function
RK1 v RK2	KB663610	2	0.48	Peptidase S1 domain-containing protein	AMIN002286	Immune response to parasites, detoxification
PV v RK2	KB663622	1.25	0.54	UDP-glucuronosyltransferase	AMIN004611	Pyrethroid resistance, detoxification
PV v RK2	KB664277	0.4	0.53	COP9 signalosome complex subunit	AMIN001615	Hormone and neural signaling
PV v RK2	KB663610	0.1	0.53	cyclic AMP-responsive element-binding protein, JNK1/MAPK8-associated membrane protein	AMIN002152, AMIN002155	G protein-coupled receptor (GPCR) signal activated transcription factor, stress response
PV v RK2	KB664266	6	0.51	Ecdysteroid UDP-glucosyltransferase	AMIN009683	Pyrethroid resistance
PV v RK2	KB663622	2.2	0.5	Methionine aminopeptidase	AMIN004701	Pyrethroid resistance, decreased susceptibility to BT toxin
PV v RK1	KB663832	1.4	0.39	Elongation of very long chain fatty acids protein	AMIN000203	Lipid concentration, metabolic detoxification
PV v RK1	KB663832	3.7	0.38			Mixed, unspecified products
PV v RK1	KB664054	2.6	0.34	NADPH–cytochrome P450 reductase, 39S ribosomal protein L22	AMIN005245, AMIN005257	Insecticide resistance, oxidative stress
PV v RK1	KB663622	1.8	0.33	csk homologous kinase domain-containing protein, translation initiation factor 1A	AMIN004659, AMIN004663	JH signaling, hemocyte activation
PV v RK1	KB663655	1	0.33			Mixed, unspecified products
TD v RK2	KB663610	0.1	0.55	Cyclic AMP-responsive element-binding protein, JNK1/MAPK8-associated membrane protein	AMIN002152, AMIN002155	G protein-coupled receptor (GPCR) signal activated transcription factor, stress response
TD v RK2	KB663832	1.3	0.55	Sodium-independent sulfate anion transporter, Protein arginine methyltransferase RmtB, Phosphate carrier- mitochondrial	AMIN000191, AMIN015783, AMIN015787	Signal transduction, phosphate carrier activated in mosquitoes by malaria infection
TD v RK2	KB663622	1.25	0.52	UDP-glucuronosyltransferase	AMIN004611	Pyrethroid resistance, detoxification
TD v RK2	KB664266	6	0.5	Ecdysteroid UDP-glucosyltransferase	AMIN009683	Pyrethroid resistance
TD v RK2	KB664277	0.4	0.49	COP9 signalosome complex subunit	AMIN001615	Hormone and neural signaling
TD v RK1	KB663832	1.25	0.5	UDP-glucuronosyltransferase	AMIN004611	Pyrethroid resistance, detoxification
TD v RK1	KB664054	2.6	0.49	NADPH–cytochrome P450 reductase, 39S ribosomal protein L22	AMIN005245, AMIN005257	Insecticide resistance, oxidative stress
TD v RK1	KB663832	3.75	0.4			Mixed, unspecified products
TD v RK1	KB663622	1.8	0.34	CHK domain-containing protein, translation initiation factor 1A	AMIN004659, AMIN004663	Mitochondrial function
TD v RK1	KB663622	3.1	0.32	Carbohydrate sulfotransferase	AMIN004763	Detoxification
TD v PV	KB663622	3.1	0.125	Carbohydrate sulfotransferase	AMIN004763	Detoxification
TD v PV	KB663832	0.6	0.049	Carboxylesterase	AMIN000169	Pyrethroid resistance and detoxification
TD v PV	KB664054	2.7	0.042	NADPH–cytochrome P450 reductase, 39S ribosomal protein L22	AMIN005245, AMIN005257	Insecticide resistance, oxidative stress
TD v PV	KB663666	0.5	0.032	Solute carrier family 6 neurotransmitter transporter	AMIN009210	Neural signaling
TD v PV	KB663832	1.35	0.027	Sodium-independent sulfate anion transporter, Protein arginine methyltransferase RmtB, Phosphate carrier- mitochondrial	AMIN000191, AMIN015783, AMIN015787	Signal transduction, a phosphate carrier activated in mosquitoes by malaria infection

Signals were identified using Fst scans in 1000 SNP windows over AminM1 contigs that were larger than 2 Mb. Genes and gene predictions near the signal peaks were identified using the VePathDB genome browser.

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Table 1 The top five Fst signals of high differentiation within each of six population comparisons are reported here.

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