Table 2 Pathways of circRNAs degradation.

Endonuclease-mediated degradation

Nuclear/cytoplasm

RNase H1, Template DNA strand

/ RNase L, PKR

Systemic lupus erythematosus

^29,33

Ago2-mediated degradation

Nuclear

miRNA, Ago2

Chronic inflammatory

pain

^35,36,37

GW182-mediated degradation

\

GW182

\

³⁸

m⁶A modification-mediated degradation

Cytoplasm

YTHDF2, HRSP12, RNase-P/MRP

Hepatocellular carcinoma

^40,41,42

Structure-mediated degradation

Cytoplasm

G3BP1, UPF1

\

⁴³

TMAO-mediated degradation

Cytoplasm

TMAO

Dysbacteriosis in gut

⁴⁵

Exosome-mediated degradation

Extracellular space

exosomes/ microvesicles

\

⁴⁸