Fig. 6: Mass response in the context of heterogeneous drug sensitivity. | Communications Biology

Fig. 6: Mass response in the context of heterogeneous drug sensitivity.

From: A pipeline for malignancy and therapy agnostic assessment of cancer drug response using cell mass measurements

Fig. 6: Mass response in the context of heterogeneous drug sensitivity.The alternative text for this image may have been generated using AI.

a Mass response measurements taken on MM1S cells, where vehicle control and carfilzomib treated cells were mixed after treatment to create cell populations with defined fractions of responding cells. b A 1:1:1 combination of MM1S, H929, and KMS-12-PE cells treated for 15 h with either single-, double-, or triple-agent therapies, demonstrating the additive signal seen as the sensitive fraction of cells increases in response to combination treatment. Multiple points indicate independent instruments, overlaid lines indicate a 95% confidence interval for mass response defined by 5000 random samples of 2500 cells. *** indicates p < 0.001, ns indicates p > 0.05.

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