Table 3 Comparison of areas under the curve (AUC) of receiver operating characteristic plots for entropy versus spectral measures.

Train on	Feature selection	Cohort	N	Test	Larger AUC	P_FDR	Entropy AUC	Spectral AUC
AS	PCA	AS	43	fcEntropy vs fcSpectral	Entropy	1.40E−41	0.938	0.747
AS	PCA	NT	37	fcEntropy vs fcSpectral	Entropy	2.40E−119	1.000	0.240
AS	PCA	Dup15q	11	fcEntropy vs fcSpectral	Entropy	2.70E−05	0.719	0.446
AS	PCA	AS	43	scEntropy vs scSpectralA	Entropy	4.75E−29	0.962	0.803
AS	PCA	NT	37	scEntropy vs scSpectralA	Entropy	2.40E−05	1.000	0.928
AS	PCA	Dup15q	11	scEntropy vs scSpectralA	Entropy	0.352	1.000	0.934
AS	PCA	AS	43	scEntropy vs scSpectralR	Entropy	1.11E−19	0.962	0.832
AS	PCA	NT	37	scEntropy vs scSpectralR	Entropy	0.557	1.000	0.988
AS	PCA	Dup15q	11	scEntropy vs scSpectralR	Entropy	0.002	1.000	0.802
AS	LMM	AS	43	fcEntropy vs fcSpectral	Entropy	3.16E−112	1.000	0.683
AS	LMM	NT	37	fcEntropy vs fcSpectral	Entropy	2.40E−119	1.000	0.156
AS	LMM	Dup15q	11	fcEntropy vs fcSpectral	Entropy	8.14E−12	0.818	0.380
AS	LMM	AS	43	scEntropy vs scSpectralA	Entropy	6.54E−77	1.000	0.738
AS	LMM	NT	37	scEntropy vs scSpectralA	Entropy	0.932	1.000	0.998
AS	LMM	Dup15q	11	scEntropy vs scSpectralA	Entropy	0.774	1.000	0.975
AS	LMM	AS	43	scEntropy vs scSpectralR	Entropy	6.19E−31	1.000	0.836
AS	LMM	NT	37	scEntropy vs scSpectralR	Entropy	0.916	1.000	0.997
AS	LMM	Dup15q	11	scEntropy vs scSpectralR	Entropy	0.142	1.000	0.901

All P-values are FDR corrected (P_FDR) for multiple testing.
AS Angelman syndrome, NT neurotypical, Dup15q duplication 15q11.2-q13.1 syndrome, PCA principal components analysis, LMM linear mixed model, scEntropy single-channel entropy, fcEntropy entropy-based functional connectivity, scSpectralA absolute spectral power, scSpectralR relative spectral power, fcSpectral spectral-based functional connectivity.

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