Fig. 5: Macrophage deletion via clodronate liposomes relieved PF and fibrotic ECM affected normal fibroblast behaviors in silicosis mice.
From: Macrophage-derived GPNMB trapped by fibrotic extracellular matrix promotes pulmonary fibrosis
a Design of the macrophage deletion experiment. b CT images, H&E staining, and Masson’s trichrome staining of lung tissue; scale bar = 200 μm. c H&E staining and Masson trichrome staining of ECM; scale bar = 200 μm. d, e Changes in cell viability and fibroblast numbers in the fibrotic ECM of silicosis mice after macrophage deletion; n ≥ 5 independent experiments, ***p < 0.001, **p < 0.01. f, g The effect of macrophage deletion on fibroblast migration induced by fibrotic ECM; scale bar = 200 μm, n ≥ 5 independent experiments, **p < 0.01. NS, normal saline.
